![]() ![]() As of 1 March 2020, a total of 79,968 cases of COVID-19 have been confirmed in mainland China including 2873 deaths. The Chinese scientists rapidly isolated a SARS-CoV-2 from a patient within a short time on 7 January 2020 and came out to genome sequencing of the SARS-CoV-2. WHO officially named the disease as coronavirus disease 2019 (COVID-19) and Coronavirus Study Group (CSG) of the International Committee proposed to name the new coronavirus as SARS-CoV-2, both issued on 11 February 2020. ![]() This coronavirus, was initially named as the 2019-novel coronavirus (2019-nCoV) on 12 January 2020 by World Health Organization (WHO). ![]() In December 2019, a cluster of pneumonia cases, caused by a newly identified β-coronavirus, occurred in Wuhan, China. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. In this review, we summarized the up-to-date information regarding COVID-19s origin, ways of spread, patients symptoms, treatment, and prevention.An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. 2019-nCoV is the third coronavirus which was detected in humans in the past two decades, after SARS-CoV and Middle Eastern Respiratory Coronavirus ( MERS-CoV) that appeared in 20, respectively. Although information about the appearance of the virus, i.e., its origin and capacity to spread among people, is still unclear, there are growing numbers of cases that are occurring from the communication of infected people with uninfected ones. Until June 3rd, 2020, this outbreak virus caused over 6,500,000 detected infection cases in 210 countries and territories and around 383,000 confirmed death cases. On March 11th, 2020, the World Health Organization ( WHO) declared COVID-19 as a global pandemic. Also, about 26 confirmed deaths have been recorded, especially for patients with serious underlying diseases. On January 24th, 2020, about 830 cases were reported in nine countries, namely China, Japan, Singapore, Thailand, South Korea, Nepal, Vietnam, the United States, and Taiwan. A novel type of coronavirus, identified as 2019-nCoV or COVID-19, appeared in Wuhan, China, in late 2019 and continued to spread in 2020. ![]()
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